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dfrA contributes to PAS resistance in M. tuberculosis. A, H37Rv overexpressing dfrA but not folC is resistant to PAS. OD, optical density. B, PAS does not inhibit rDHFR enzymatic activity as compared with the specific DHFR inhibitor WR99210 with the DHFR assay. The values represent the means ± S.D. from one representative experiment performed with triplicate samples.
