Figure 4. Difference in cytokine expression levels and correlations across HH grades (A) and difference in cytokine levels across patients with good and poor admission status (at T₁) stratified by HH ≤ 3 (white) vs HH ≥ 4 (gray).

Interleukin (IL)-6 (A), CCL2 (B), CCL11 (C), and colony-stimulating factor-3 (CSF3) (D) were elevated in the Hunt-Hess (HH) ≥ 4 group. The unadjusted p values indicate possible elevation of IL-8 (E), IL-10 (F), CX3CL1 (G), and tumor necrosis factor (TNF)-α (H) in the HH ≥ 4 group (B and C). aSAH = aneurysmal subarachnoid hemorrhage; EGF = epidermal growth factor; FGF2 = fibroblast growth factor-2; FLT3L = FMS-like tyrosine kinase 3 ligand; IFNA2 = interferon-α2; IFNG = type-II interferon family; IL = interleukin; IP10 = interferon-inducible protein 10; MIP1B = macrophage inflammatory protein-1β; PDGF = platelet-derived growth factor; VEGF = vascular endothelial growth factor. *Significant p values represent the Benjamini-Hochberg–adjusted (false discovery rate 10%) values.