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. Author manuscript; available in PMC: 2017 Apr 18.
Published in final edited form as: Biochimie. 2017 Jan 3;134:35–50. doi: 10.1016/j.biochi.2016.12.016

Fig. 8. Conserved symmetrical elements of the mitochondrial ADP/ATP carrier and uncoupling protein.

Fig. 8

Lateral view of the yeast ADP/ATP carrier Aac2p [105] (left) and uncoupling protein 1 (right), a comparative model using the yeast Aac3p [105] and bovine AAC1 [41] structures, in cartoon representation. Aromatic and hydrophobic residues of the [FY]XX[YF] motif are shown in orange and pink ball-and-stick representations, respectively. Proline residues of the PX[DE]XX[KR] motif are shown in a magenta ball-and-stick representations, whereas the serine residue in Aac2p, which mimics a proline residue, is shown in a green ball-and-stick representation. Positively charged residues, found two positions after the PX[DE]XX[KR] motif, and negatively charged residues of the [ED]G motif are shown in blue and red ball-and-stick representations, respectively, whereas a hydrophobic substitution of a positively charged residue in Aac2p is shown in pink.