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Lysophagy can be induced by a variety of stimuli that can lead to lysosome damage. Upon lysosomal injury, galectin-3 and LC3 are recruited to the injured lysosome. Lysosomal membranes are ubiquitinated and co-localize with p62, suggesting that ubiquitination and subsequent recruitment of p62 are involved in this process. However, the exact mechanisms of lysophagy regulation are still unclear.
