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The respiratory burst is impaired in Gaucher macrophages. (A, B). The production of reactive oxygen species (ROS) production was measured in Gaucher macrophages [(A) genotype N370S/N370S or (B) N370S/L444P] after engulfing apoptotic Jurkat cells (AJ) in the presence or absence of erythrocyte ghosts. In addition, 5 mM ATP was added to serum-free media (after centrifugation to remove media from the apoptotic Jurkat cells) in the presence or absence of added apoptotic Jurkat cells.
