Table 4. Univariate and multivariate analysis of prognostic parameters of breast cancer death.

		OR (95% CI)	p-value
Univariate analysis
Tumor size	≤20 mm vs. >20 mm	2.2 (1.3–3.5)	0.001
NHG	I+II vs. III	3.0 (1.8–4.9)	0.00
Ki67	≤22% vs. >22% [28, 33]	1.7 (1.1–2.6)	0.02
HER2	Negative vs. positive	0.9 (0.4–2.1)	0.83
Age	<70 yrs vs. ≥70 yrs	2.4 (1.5–3.9)	0.00
Ghrelin intensity	0 vs. 1+2+3 [19]	0.6 (0.4–0.8)	0.006
Obestatin intensity	0 vs. 1+2+3 [19]	1.2 (0.6–2.5)	0.59
Multivariate analysis
Ghrelin intensity*	0 vs. 1+2+3 [19]	0.6 (0.4–0.9)	0.007
Endocrine treatment	Negative vs. positive	1.0 (0.6–1.7)	0.93
Ghrelin intensity**	0 vs. 1+2+3 [19]	0.6 (0.4–0.9)	0.01
Endocrine treatment	Negative vs. positive	1.0 (0.6–1.7)	0.95
Age	<70 yrs vs. ≥70 yrs	2.4 (1.4–3.9)	0.001

Odds ratio (OR) and 95% confidence intervals (CI) obtained from univariate and multivariable Cox conditional logistic models. HER2, human epidermal growth factor receptor 2; NHG, Nottingham Histological Grade.

*Model adjusted for endocrine treatment.

**Model adjusted for endocrine treatment and age.