Fig 1. Chaetocin inhibits cell viability in melanoma cells.

Cells (A375, Sk-Mel-28, IGR37, LU-1205, MV3, and normal melanocytes) were treated with different doses of chaetocin for 24 h, and cell viability was determined by MTT assay. (A) Chaetocin suppressed cell proliferation in a dose-dependent manner. (B) The IC₅₀ was determined when various cells were treated by chaetocin for 24 h. (C-D) Sk-Mel-28 and A375 cells were treated with 10 μM chaetocin for 24, 48 and 72 h, and displayed a time-dependent inhibitory effect on cell viability. Data represented as means ± SEM (n = 3). *P< 0.05 and **P< 0.01, with the untreated controls. ^#P< 0.05, compared with normal melanocytes.