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. 2017 Apr 18;12(4):e0175950. doi: 10.1371/journal.pone.0175950

Fig 4. Chaetocin treatment produces ROS and N-Acetyl Cysteine (NAC) reduces chaetocin-induced apoptotic effects in human melanoma cells.

Fig 4

(A-B): Chaetocin treatment resulted in ROS generation in Sk-Mel-28 (A) and A375 (B) cells, as detected by a fluorescence plate reader. Data represented as means ± SEM (n = 3). **P< 0.01, compared with controls. (C-D): NAC pre-treatment reduced chaetocin-induced ROS generation in Sk-Mel-28 (C) and A375 (D) cells. (E-F) NAC pre-treatment attenuated chaetocin-induced apoptosis in Sk-Mel-28 (E) and A375 (F) cells. Data represented as means ± SEM (n = 3). **P< 0.01.