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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: J Proteome Res. 2016 Dec 2;16(2):609–618. doi: 10.1021/acs.jproteome.6b00698

Figure 5.

Figure 5

C-score distributions for the three experimental setups. Identified proteoforms are binned according to their associated C-scores. Panels A–C show C-score distributions for data-dependent high–high, AUTOPILOT high/high, and data-dependent medium/high results, respectively. Proteoforms with a C-score lower than 3 are considered statistically identified but not well characterized. Proteoforms with a C-score between 3 and 40 are defined as partially characterized, as the set of fragment ions used for their identification might be consistent also with the presence of one or more highly similar proteoform(s). Finally, proteoforms with a C-scores >40 are considered well characterized, and their respective PFRs are included in a top-down proteoform repository.