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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Mar 10;27(8):1744–1749. doi: 10.1016/j.bmcl.2017.02.070

Table 2.

a. Heterocyclic Replacements for Benzamide

graphic file with name nihms859149u3.jpg
Cmpd Ar SRE.L IC50 (μM) MLM T1/2 (min) ClogP TPSA
1 graphic file with name nihms859149t1.jpg 0.64 1.6 4.25 62.6
4a graphic file with name nihms859149t2.jpg 2.9 < 3 3.03 75.4
4b graphic file with name nihms859149t3.jpg 1.9 < 3 3.41 75.4
4c graphic file with name nihms859149t4.jpg 15.3 3.09 88.3
4d graphic file with name nihms859149t5.jpg 5.3 2.86 91.2
4e graphic file with name nihms859149t6.jpg 6.8 2.92 88.6
4f graphic file with name nihms859149t7.jpg 6.2 3.56 103.7
4g graphic file with name nihms859149t8.jpg 5.8 3.33 103.7
a

Assay descriptions provided in Table 1.