Table 4.

^a. Heteroaryl Carboxamide Analogs

Cmpd	HET	X	Y	R	SRE.L IC50 (μM)	MLM T1/2 (min)	Sol (μg/mL)	ACTA2 (%ctrl)	ClogP	TPSA
1	2-furanyl	CH	CH	H	0.64	1.6	13.4	37	4.25	62.55
8b	1-Me-5-imidazoyl	CH	CH	F	0.37	16	14.9	110	3.24	67.2
8c	2-imidazolyl	CH	CH	F	5.5				3.39	78.1
8d	2-pyridyl	CH	CH	F	1.0	9.5	3.9	37	4.38	62.3
8e	3-pyridyl	CH	CH	F	0.90	< 3			4.00	62.3
8f	4-pyridyl	CH	CH	F	0.55	7.8	23.1	31	4.00	62.3
8g	2-pyrimidinyl	CH	CH	F	3.0	11.9	75.4	65	4.05	75.2
8h	5-pyrimidinyl	CH	CH	F	3.2				3.29	75.2
8i	1-pyrazolyl	CH	CH	F	0.68	4.8	23	140	3.65	67.2
8j	4-pyrazolyl	CH	CH	F	4.5	13			3.52	78.1
8k	4-pyridyl	CF	CH	F	0.53	6.9	9.8	14	4.14	62.3
8l	4-pyridyl	N	CH	F	1.2	7.7	62	190	2.78	75.2
8m	2-furanyl	CH	N	F	7.1	2.5			3.44	75.4
8n	2-furanyl	N	CH	F	3.5	3.0			3.06	75.4
9c	1-imidazolyl	CH	CH	H	5.2				2.46	67.2
9i	1-pyrazolyl	CH	CH	H	2.9	1.7			3.62	67.2
9j	4-pyrazolyl	CH	CH	H	3.0	5.6	73	73	3.49	78.1
9o	3-pyrazolyl	CH	CH	H	0.92	3.4			3.88	78.1

^aAssay descriptions provided in Table 1.