Skip to main content
. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Mar 10;27(8):1744–1749. doi: 10.1016/j.bmcl.2017.02.070

Table 5.

Single dose plasma exposure in mice

Route IP PO
Cmpd AUCa AUCa Concb (0.5 h) Concb (7 h)
1 (CCG-203971) 1200
8a (CCG-222740) 9200
8f (CCG-232601) 15251 33719 14.4 2.4
8k (CCG-257081) 26700 36385 13.2 1.3
a

Estimated area under the plasma concentration curve (0–7 hrs, hr.ng/mL) following a single dose by intraperitoneal injection (10 mg/kg) or oral gavage (20 mg/kg).

b

Plasma concentration at time indicated (μM).