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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Bone Miner Res. 2017 Feb 27;32(4):821–833. doi: 10.1002/jbmr.3045

Fig. 3.

Fig. 3

Fluoxetine treatment disrupts intramembranous bone formation and results in smaller bony regenerate. (A–D) Aniline blue staining of representative longitudinal sections through monocortical defect sites. (E) Histomorphometric analysis of bony regenerate size (n = 4, p = 0.04 [POD7], p < 0.001 [POD14]). (F–I) 3D reconstruction of µCT analysis of the monocortical defect site at 7 and 14 days. (J–L) Analysis of µCT data showing BV/TV, Tb.N, Tb.Th, and Tb.Sp (n = 4, p < 0.05). Asterisk denotes statistical significance. Scale bar = 500 µm. d = day; POD = postoperative day; BV/TV = bone volume/total volume; Tb.N = trabecular number; Tb.Th = trabecular thickness; Tb.Sp = trabecular spacing.