Skip to main content
. Author manuscript; available in PMC: 2017 Sep 13.
Published in final edited form as: Nat Immunol. 2017 Mar 13;18(5):541–551. doi: 10.1038/ni.3690

Figure 4.

Figure 4

Transferring microbiota from Nlrp12−/− mice induces colonic inflammation. (a) Body weight, (b) percent survival, (c) DAI and (d) colon length of GF WT vs. GF Nlrp12−/− mice reconstituted with fecal material (FM) from SPF WT or Nlrp12−/− mice and treated with DSS (FMWT→GF WT, n=11; FMNlrp12−/−→GF WT, n=10; FMWT→GF Nlrp12−/−, n=9; and FMNlrp12−/−→GF Nlrp12−/−, n=9), compiled from 2 independent experiments. (e) Immunoblots and densitometry of distal colon proteins from mice described in (a–d). Error bars show SEM. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 and n.s. indicates no significance determined using two-tailed unpaired t test (a, e), Log-rank (Mantel Cox) test (b) and one-way ANOVA Fisher’s LSD test (c–d).