Table 2.
Associations of MG53 rs7186832 and rs12929077 with T2D in Nantong population
| SNP | Group | WT/Ht/MT | Additive model (WT vs Ht vs MT) | Dominant model (WT vs Ht + MT) | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95 % CI)a | OR (95 % CI)b | OR (95 % CI)c | OR (95 % CI)a | OR (95 % CI)b | OR (95 % CI)c | |||
| rs7186832 | TT/TC/CC | |||||||
| NGT | 637/282/38 | 1.03 (0.89–1.18) | 1.03 (0.89–1.18) | 1.21 (1.03–1.40) | 1.06 (0.91–1.24) | 1.07 (0.91–1.26) | 1.31 (1.1–1.57) | |
| IFG | 360/142/20 | P = 0.717 | P = 0.680 | P = 0.014 | P = 0.489 | P = 0.439 | P = 0.003 | |
| T2D | 502/247/26 | |||||||
| rs12929077 | AA/AG/GG | |||||||
| NGT | 570/343/41 | 0.99 (0.86–1.13) | 0.99 (0.87–1.14) | 1.13 (0.98–1.32) | 1.01 (0.86–1.17) | 1.02 (0.87–1.19) | 1.18 (1.02–1.39) | |
| IFG | 320/182/16 | P = 0.850 | P = 0.070 | P = 0.089 | P = 0.968 | P = 0.825 | P = 0.049 | |
| T2D | 459/283/29 | |||||||
SNP single nuclear polymorphisms, WT wild type, Ht heterozygote, MT mutant type, OR odds ratio, CI confidence interval, NGT normal glucose tolerance, IFG impaired fasting glucose, P probability, T2D type 2 diabetes
aP value of χ2 test for comparison of genotype between case and control groups
bOrdinal multinomial logistic regression analysis adjusted for age, gender and PAI
cOrdinal multinomial logistic regression analysis adjusted for age, gender, BMI and PAI