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. 2017 Apr 19;7:133. doi: 10.3389/fcimb.2017.00133

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Copyright © 2017 Yang, Xie, Jia, Liu, Liang, Wu, Liang, Li, Wang, Sheng, Li, Liu, Ma, Yang, Du, Qiu and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathogenesis of EV71 infection in mice. (A) Survival rates of EV71 infected mice vs. negative control mice. (B) Weight gain in EV71 infected mice. Mice were monitored for 7 days. Data are presented as mean ± standard deviation (SD), n = 3, ^*P < 0.05. (C) Virus titer in EV71 infected mice brain, n = 3. (D) Clinical symptoms of EV71 infected mice, n = 10, data are presented as mean ± SD. (E) HE staining of mouse brain sections. NC, IF DAY3, and IF DAY5 represent uninfected negative control, and EV71 infected at 3 dpi and 5 dpi, respectively. The red arrows indicate monocyte infiltration.