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. 2017 Apr 19;11:194. doi: 10.3389/fnins.2017.00194

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Copyright © 2017 Hartmann, Muth, Dabrowski, Krasemann and Glatzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomal PrP^C: spreading or trapping of neurotoxic proteins in neurodegeneration. Role in prion diseases (left): transport of PrP^Sc via exosomes secreted from a prion-infected cell or binding of PrP^Sc to exosomal PrP^C may enhance transmission and spreading. Role in AD (right): capturing and detoxifying of neurotoxic Aß-peptides by exosomal PrP^C may act neuroprotective. Aß-fibrils bound to exosomes may contribute to Aß plaque formation or may enable uptake and degradation by microglia.