Figure 1.

Decision tree for the choice of method for predicting a release/absorption profile. If a suitable model for the release/absorption profile exists or can be constructed, parametric methods are suitable. Otherwise, non-parametric methods can be used. The method presented in this paper addresses the most general non-parametric case, with non-linear PK and without any steady-state assumptions. If linearity or steady-state conditions can be assumed, simplifications can be made in order to reduce the computational requirements. IV = intravenous administration.