Table 1.

Pharmacokinetic parameters, from Gao and Jusko (2012).

Parameter	Definition	Value	Unit
kel	Elimination rate constant	0.013	min−1
kpt	Intercompartmental rate constant	0.0685	min−1
ktp	Intercompartmental rate constant	0.0846	min−1
Vc	Central volume of distribution	111	ml⋅kg−1
kon	Second-order binding constant	0.000411	pM−1⋅min−1
koff	First-order dissociation constant	0.566	min−1
kint	Internalization rate constant	0.00342	min−1
Rtot	Total receptor concentration	1,240	pM