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. 2017 Apr 19;7:128. doi: 10.3389/fcimb.2017.00128

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Copyright © 2017 Bose, Venkatesh and Mande.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the interlogs approach. (A) Interlog based mapping approach for predicting intra-species PPIs. If A–A′ and B–B′ are orthologous sets of protein in two organisms X and Y and the proteins A and B are known to interact in organism X, then the interlog based mapping approach concludes a possible PPI between the proteins A′ and B′ in organism Y. (B) Modified (inter-species) interlog method that was employed for predicting the HPIs. X represents the host and Y represents the pathogen (or vice versa). If protein A and protein B of organism X are known to interact among each other, and if there exists a homolog to protein A (protein A′) in organism Y, then the modified interlog method assumes that protein A′ will also interact with protein B through a PPI.