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. 2017 Apr 19;8:422. doi: 10.3389/fimmu.2017.00422

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Copyright © 2017 Wolin, Lahtela, Anttila, Petrek, Grunewald, van Moorsel, Eklund, Grutters, Kolek, Mrazek, Kishore, Padyukov, Pietinalho, Ronninger, Seppänen, Selroos and Lokki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The meta-analysis of Löfgren (LS) vs. controls with Finnish, Swedish, and Czech samples. The linkage disequilibrium (LD) information (r²) is shown by color-coded dots and the recombination rates where the peaks are the hotspots are based on the HapMap data. The LD structure (r²) in the current study for the top significant SNPs (I² < 25) are shown on the right. After adjusting for HLA-DRB1 alleles, the SNPs that remained significant are pointed with an arrow.