Table 1.
Physical and biochemical characteristics of the 25 monozygotic twin pairs at baseline
| Parameter | Pairs discordant for weight, n = 16 |
Pairs concordant for weight, n = 9 |
|||
|---|---|---|---|---|---|
| DH co-twin | DL co-twin | P | Nonobese pairs, n = 6 | Obese pairs, n = 3 | |
| Sex | 4 male/12 female pairs | 3 male/3 female | 2 male/1 female | ||
| Age [mean (min and max) yr] | 25.0 (24.4, 32.1) | 30.5 (29.6, 31.1) | 31.9 (25.6, 32.8) | ||
| Use of oral contraceptive medication | 5/6 | 6/6 | 1/3 | 1/1 | |
| BMI (kg/m2) | 30.2 (26.4, 34.1) | 24.0 (21.9, 27.4) | <0.001 | 26.6 (25.6, 27.5) | 32.7 (29.8, 34.5) |
| Intra-abdominal fat (cm3) | 1047 (656, 1775) | 571 (327, 800) | <0.001 | 926 (232, 1261) | 1445 (948, 1630) |
| Subcutaneous fat (cm3) | 5947 (4364, 7878) | 3717 (2622, 4850) | <0.001 | 2644 (2476, 4409) | 4628 (3296, 6124) |
| Body fat (%) | 43.3 (34.5, 47.6) | 35.2 (28.5, 40.4) | <0.001 | 29.7 (22.7, 39.3) | 37.1 (27.9, 41.4) |
| Liver fat (%) | 0.9 (0.6, 4.9) | 0.6 (0.4, 0.9) | <0.01 | 1.1 (0.3, 1.7) | 1.2 (0.5, 4.9) |
| Serum total cholesterol (mM) | 4.3 (3.9, 4.9) | 4.6 (3.9, 4.8) | 0.75 | 4.3 (3.3,5.1) | 4.4 (3.7, 5.4) |
| Serum HDL cholesterol (mM) | 1.3 (1.1, 1.5) | 1.7 (1.3, 2.0) | <0.01 | 1.4 (1.0,1.5) | 1.2 (1.0,1.3) |
| Serum LDL cholesterol (mM) | 2.7 (2.4, 3.0) | 2.5 (2.1, 2.9) | 0.14 | 2.7 (1.8, 3.7) | 2.8 (2.2, 3.1) |
| Serum triglycerides (mM) | 1.1 (0.8, 1.3) | 1.0 (0.8, 1.2) | 0.37 | 1.0 (0.6,1.1) | 1.8 (0.5, 2.8) |
| Serum glucose (mU/L) | 5.5 (5.2, 5.8) | 5.3 (5.2, 5.4) | 0.15 | 5.3 (5.0, 5.4) | 6.0 (5.7, 6.2) |
| Serum insulin (mU/L) | 8.7 (5.2, 13.3) | 6.5 (4.7, 8.3) | 0.03 | 5.5 (4.3, 7.2) | 6.8 (5.7, 13.3) |
| Serum high-sensitivity CRP (mg/L) | 1.3 (0.6, 5.8) | 1.1 (0.5, 4.1) | 0.43 | 0.6 (0.3, 1.7) | 1.4 (1.0, 2.1) |
| Matsuda index | 4.6 (3.5, 7.5) | 6.6 (4.4, 9.0) | 0.13 | 10.3 (4.9, 14.7) | 5.2 (2.4, 8.5) |
Data are presented as medians with interquartile range in parentheses. P values are for DH vs. DL co-twins for weight; paired Wilcoxon's test.