Table 5.

Association between hormone levels and the MMSE and EPIC scores: multivariate analysis

MMSE
6Mo hormone levels		B	Odds ratio	95% CI	p
	E2	-1.47	0.23	0.073-0.724	0.012
	A-dione	0.021	1.02	1.006-1.036	0.006
	cortisol	-0.059	0.94	0.898-0.989	0.016
EPIC
Hormone levels and QOL at each observation point
PRE
Sexual bother	A-dione	-0.02	0.98	0.964-0.997	0.019
6Mo
Sexual bother	E2	1.57	4.81	1.086-21.33	0.039
	T	-61.15	2.76 × 10-27	1.34 × 10-5-0.00057	0.026
	DHT	0.21	1.017	1.028-1.484	0.024
Hormonal function	E2	1.14	3.12	1.13-8.64	0.028
	A-dione	-0.019	0.98	0.97-0.998	0.026
Hormonal bother	E2	2.006	7.44	1.82-30.30	0.005
	T	-30.8	4.19 × 10-14	4.32 × 10-24-0.00041	0.017
	cortisol	0.076	1.08	1.02-1.14	0.008
12Mo
Sexual bother	E2	1.082	2.95	1.11-7.82	0.030
Hormonal bother	A-dione	-0.0089	0.991	0.983-0.9997	0.042
	DHEA-S	-0.0174	0.983	0.966-0.999	0.049

B: regression coefficient.

PRE: pretreatment 6MO: 6 months after initiation of LH-RH agonist treatment.

12MO: 12 months after initiation of LH-RH agonist treatment.

T: testosterone, DHT: dihydrotestosterone, E2; estradiol, DHEA-S: dehydroepiandrosterone-sulfate.

A-dione: androstenedion, MMSE: mini-mental state examination.

EPIC: expanded postate cancer index composite.