Table 6.
Baseline characteristics of patients in subgroups A0-A4. Data show percentages (numbers of patients) unless stated otherwise
| A0 (n = 212) | A1 (n = 96) | A2 (n = 107) | A3 (n = 130) | A4 (n = 95) | |
|---|---|---|---|---|---|
| Mean age in years (SD) | 62.1 (13.8) | 66.1 (14.1) | 65.1 (14.2) | 63.1 (14.7) | 62.1 (15.2) |
| Male | 61.8 (131) | 59.4 (57) | 58.9 (63) | 50.8 (66) | 52.6 (50) |
| New York Heart Association class | |||||
| I | 3.3 (7) | 3.1 (3) | 3.7 (4) | 5.4 (7) | 3.2 (3) |
| II | 39.6 (84) | 34.4 (33) | 43.9 (47) | 30.8 (40) | 33.7 (32) |
| III | 48.6 (103) | 54.2 (52) | 45.8 (49) | 52.3 (68) | 56.8 (54) |
| IV | 8.5 (18) | 8.3 (8) | 6.5 (7) | 11.5 (15) | 6.3 (6) |
| Race | |||||
| White | 56.1 (119) | 56.3 (54) | 63.6 (68) | 56.9 (74) | 56.8 (54) |
| Black | 27.8 (59) | 36.5 (35) | 34.6 (37) | 36.9 (48) | 38.9 (37) |
| Other | 16.0 (34) | 7.3 (7) | 1.9 (2) | 6.2 (8) | 4.2 (4) |
| Hispanic or Latino ethnic group | 1.4 (3) | 2.1 (2) | 1.9 (2) | 4.6 (6) | 3.2 (3) |
| LVEF < 40%a | 70.8 (148) | 71.7 (66) | 62.1 (64) | 66.7 (84) | 62.4 (58) |
| Chronic kidney diseaseb | 58.2 (121) | 58.3 (56) | 62.3 (66) | 50.8 (66) | 57.4 (54) |
| COPD | 20.3 (43) | 28.1 (27) | 21.5 (23) | 16.2 (21) | 18.9 (18) |
| Diabetes mellitus | 52.4 (111) | 54.2 (52) | 54.2 (58) | 53.8 (70) | 46.3 (44) |
| Hypertension | 70.3 (149) | 78.1 (75) | 76.6 (82) | 77.7 (101) | 75.8 (72) |
| Coronary artery disease | 57.5 (122) | 63.5 (61) | 56.1 (60) | 61.5 (80) | 58.9 (56) |
| Mean blood pressure (SD) | |||||
| Systolic | 122.1 (23.8) | 122.1 (25.4) | 120.1 (22.5) | 123.1 (24.6) | 121.1 (24.5) |
| Diastolic | 70.1 (13.8) | 70.1 (14.3) | 70.1 (12.2) | 70.1 (13.6) | 71.1 (12.7) |
| Mean serum potassium (SD)c | 4.1 (0.6) | 4.1 (0.5) | 4.1 (0.6) | 4.1 (0.6) | 4.1 (0.5) |
| Mean blood urea nitrogen (SD)d | 30.1 (20.3) | 27.1 (16.3) | 30.1 (16.7) | 28.1 (18.8) | 27.1 (15.4) |
| Mean serum creatinine (SD)e | 2.1 (0.9) | 1.1 (0.8) | 2.1 (0.9) | 1.1 (0.8) | 1.1 (0.7) |
| Mean weight in lbs. (SD) | 169.1 (79.6) | 175.1 (72.5) | 173.1 (76.1) | 170.1 (73.2) | 173.1 (67.3) |
| Medications | |||||
| ACE inhibitor or ARB | 69.8 (148) | 64.6 (62) | 66.4 (71) | 70.0 (91) | 62.1 (59) |
| Aldosterone-receptor antagonist | 36.3 (77) | 31.3 (30) | 29.0 (31) | 33.1 (43) | 31.6 (30) |
| Beta blocker | 84.4 (179) | 84.4 (81) | 80.4 (86) | 82.3 (107) | 82.1 (78) |
| Digoxin | 27.4 (58) | 28.1 (27) | 20.6 (22) | 22.3 (29) | 28.4 (27) |
| Loop diuretic | 81.1 (172) | 79.2 (76) | 79.4 (85) | 83.1 (108) | 77.9 (74) |
| Did not graduate high schoolf | 21.3 (43) | 23.7 (22) | 23.5 (24) | 26.1 (31) | 24.2 (22) |
| Household income < $10,000 pag | 23.1 (39) | 22.4 (17) | 17.3 (14) | 26.9 (28) | 21.3 (16) |
a N = 209, 92, 103, 126, 93
b N = 208, 96, 106, 130, 94
c N = 204, 95, 104, 128, 93
d N = 206, 94, 102, 126, 92
e N = 208, 96, 106, 130, 94
f N = 202, 93, 102, 119, 91
g N = 169, 76, 81, 104, 75