Table 1.
Clinical findings, HTLV-1 subtype, proviral loads, and HTLV-1 sequence changes in patients of HAM/TSP and ACs
| f-HAM/TSP (n = 30) | s-HAM/TSP (n = 92) | ACs (n = 89) | p value | |
|---|---|---|---|---|
| Age (years old) | 54.7 ± 13.3 | 58.4 ± 13.2 | 52.7 ± 14.4 | 0.021 |
| Male (N, %) | 5, 17% | 29, 32% | 36, 40% | 0.052 |
| Transcontinental/Japanese subtype (n) | 10/20 | 21/71 | 6/83 | <0.001 |
| Anti-HTLV-1 antibodiese | 20,992 ± 33,571 (N = 29) | 30,707 ± 43,985 (N = 80) | 7667 ± 17,209 (N = 80) | <0.001 |
| HTLV-1 proviral loads (copies/104 PBMCs) | 819 ± 743 | 813 ± 936 | 366 ± 657 | <0.001 |
| No. of SNPs (reference AB513134)a | 34.2 ± 18.7 | 29.6 ± 19.2 | 22.3 ± 12.0 | 0.004 |
| No. of SNPs (each reference)b | 21.4 ± 6.8 | 20.3 ± 7.5 | 19.5 ± 5.3 | 0.392 |
| No. of G-to-A mutations (reference AB513134)c | 10.2 ± 4.6 | 8.9 ± 4.4 | 7.4 ± 3.2 | 0.003 |
| No. of G-to-A mutations (each reference)d | 6.6 ± 2.5 | 6.3 ± 2.4 | 6.7 ± 2.2 | 0.422 |
Data are mean ± SD
f-HAM/TSP familial HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, s-HAM/TSP sporadic HAM/TSP patients, ACs asymptomatic HTLV-1 carriers
aNumber of SNPs of complete HTLV-1 sequences using the data mapped to AB513134
bNumber of SNPs of complete HTLV-1 sequences using the data mapped to each reference; transcontinental subtype, consensus transcontinental reference; Japanese subtype, AB513134
cNumber of G-to-A mutations of complete HTLV-1 sequences using the data mapped to AB513134
dNumber of G-to-A mutations of complete HTLV-1 sequences using the data mapped to each reference; transcontinental subtype, consensus transcontinental reference; Japanese subtype, AB513134
eParticle aggregation method