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. 2017 Apr 19;7:46489. doi: 10.1038/srep46489

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Adult (8 week) hUGT1/Car^−/− and hUGT1/Car^+/− mice were treated by p.o administration with 200 mg/kg/day for four days. After treatment, RNA and total cell extracts were prepared. (A) From liver tissue, UGT1A1 and Cyp2b10 gene expression was analyzed by real time PCR and expressed as Fold induction. From the same tissues, total cell extracts were combined and used for Western blot analysis using anti-human UGT1A1 and anti-mouse CYP2B10 antibodies. The bands have been cropped from the full-length blots but not enhanced in anyway (S7). (B) From small intestine, a similar series of experiments were performed. Values are the means of ±SD (n > 3). Statistically significant differences between vehicle (Veh) and PEITC are indicated by asterisks (Student t test: *P < 0.05).