Table 1.

Interaction effects on tRNA p9 site methylation

Cancer	p9 Site	rs number	Chr	Position	Location	Gene	N	MAF	MAF range	P value
BRCA	7526	rs3781574	11	33885268	intron	LMO2	46	0.161	0.128–0.231	4.61E-11
BRCA	7526	rs17690328	11	33885390	intron	LMO2	46	0.135	0.016–0.190	1.17E-08
BRCA	7526	rs317391	17	32174605	intron	ASIC2	44	0.085	0.014–0.485	2.46E-09
KIRC	1610	rs258701	7	81761122	intron	CACNA2D1	61	0.058	0.072–0.167	8.27E-10
KIRC	8303	rs10266772	7	14132727	Intergenic	-	61	0.080	0.079–0.254	2.27E-08
KIRC	10413	rs1028014	8	40698232	intron	ZMAT4	64	0.174	0.085–0.236	2.88E-08
KIRC	12146	rs17164416	5	99387447	Intergenic	-	65	0.051	0.000–0.188	9.95E-09
LIHC	12146	rs41465346	1	219059708	Intergenic	-	48	0.052	0.006–0.304	3.73E-08
LIHC	12146	rs16926871	8	62027498	intron	CLVS1	47	0.074	0.038–0.270	1.24E-08
LUAD	585	rs13029285	2	205916078	intron	PARD3B	49	0.057	0.003–0.076	1.81E-10
LUAD	10413	rs7328699	13	28615701	intron	FLT3	46	0.107	0.000–0.124	9.15E-10
LUAD	10413	rs12591927	15	31833911	intron	OTUD7A	44	0.077	0.016–0.289	2.44E-08
LUAD	10413	rs17003208	22	43073031	Intergenic	-	45	0.074	0.096–0.431	1.13E-08
LUAD	10413	rs17003212	22	43079754	Intergenic	-	46	0.063	0.096–0.434	1.18E-11
LUAD	12146	rs4741498	9	15424938	intron	SNAPC3	45	0.063	0.005–0.256	3.68E-08
LUAD	12146	rs7026970	9	15445219	intron	SNAPC3	45	0.063	0.040–0.355	3.68E-08
LUAD	12146	rs7046713	9	15458921	intron	SNAPC3	45	0.063	0.031–0.357	3.68E-08
LUAD	14734	rs341737	8	2782370	Intergenic	-	54	0.107	0.081–0.225	9.86E-09
PRAD	10413	rs7631369	3	1028679	Intergenic	-	48	0.070	0.015–0.418	3.45E-08
PRAD	10413	rs7301597	12	30175147	Intergenic	-	48	0.050	0.000–0.105	3.85E-09
THCA	585	rs17033484	4	156686737	intron	GUCY1B3	54	0.089	0.058–0.187	3.78E-08
THCA	4271	rs2145836	20	47421064	intron	PREX1	44	0.054	0.000–0.058	4.41E-08

MAF denotes minor allele frequency of the polymorphism in TCGA data for the specific cancer type, and MAF range denotes the range of minor allele frequencies across continents observed in 1000 Genomes phase 3 data [41]