Table 4B. Logistic regression analysis of IL-8(-251), IP-10(-1596), and main clinical features in the association with diabetic retinopathy.
| Variable |
DR |
|
|---|---|---|
| OR (95%CI) | P-value | |
| IL-8(-251T/A) | 0.71 (0.59–0.84) | 0.001 |
| IP-10(-1596C/T) | 0.40 (0.26–0.57) | <0.001 |
| Age | 0.92 (0.75–1.18) | 0.61 |
| Gender | 0.76 (0.45–1.11) | 0.25 |
| Duration of diabetes | 0.82 (0.51–1.25) | 0.44 |
| Body mass index (kg/m2) | 0.66 (0.42–1.09) | 0.12 |
Multiple logistic regression analyses were conducted and showed that independent effects of these SNPs in DR susceptibility remained significant (P<0.05) when conditioning on each other and main clinical features.