Figure 1.

Graphical representation of the AR pathway model workflow presented here. The internal process consisted of generating HTS data on 11 AR assays and building a computational model of AR pathway agonist/antagonist activity. The external process involved systematic literature review for reference data and curation of the reference chemical list based on published data. The model performance was evaluated against the reference chemicals, and screening results from the validated model on a large set of environmental chemicals are presented. AR = androgen receptor, HTS = high-throughput screening data.