Table 3. Schema for Antagonist Activity Confidence Scoring.
| source | criteria | confidence score contributiona |
|---|---|---|
| AR pathway model | AUC.R2 > 0.1 | 2 |
| 0.1 > AUC.R2 > 0.001 | 1 | |
| cell stress/cytotoxicity flag | average Z-score > 3 | 1 |
| confirmation assay data | true antagonist shift (hit/hit) | 3 |
| true antagonist shift (no hit/hit) | 2 | |
| FLAG: true antagonist shift but CI overlap | 1 | |
| FLAG: wrong direction shift (hit/hit) | –1 | |
| FLAG: wrong direction (hit/no hit) | –1 |
a
Contributions from the three source categories are summed to provide an overall antagonist activity confidence score ranging from −1 to 6.