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Incorporation of siRNA did not interfere with TPPS PDT activity. ES-2 ovarian carcinoma cells treated for 72 hours with cESG-TPPS or cESG-TPPS-siRNA (siRNA targeted at Sod2) prior to 10 minute illumination with light. MTT viability was assessed 24 h after light treatment (Mean ± SEM, n=4 independent experiments. *p<0.05 **p<0.01 ***p<0.001 determined by one-way ANOVA with Tukey’s post-hoc test).
