Table 4. Factors associated with liver stiffness measurement ≥ 8.0 kPa in univariate and multivariate analyses in patients with non-alcoholic fatty liver disease.

Variables	Univariate analysis	P Value	Multivriate analysis	P Value
	OR (95% CI)		OR (95% CI)
Age, years	1.03 (1.00–1.06)	0.078	1.02 (0.97–1.06)	0.47
Male	1.15 (0.62–2.14)	0.657	1.33 (0.55–3.20)	0.53
BMI
Normal; BMI <24 (kg/m2)	1.00 (reference)		1.00 (reference)
Overweight; 24 ≤ BMI < 30 (kg/m2)	2.49 (1.29–4.81)	0.006	4.13 (1.69–10.10)	0.002
Obese; BMI ≥30 (kg/m2)	3.18 (0.87–11.61)	0.079	9.44 (1.80–49.49)	0.008
DM (%)	1.00 (0.54–1.88)	0.992	0.64 (0.28–1.42)	0.27
AST (IU/L)	1.11 (1.06–1.17)	<0.001	1.21 (1.11–1.31)	<0.001
ALT (IU/L)	1.02 (0.99–1.05)	0.218	0.93 (0.87–0.99)	0.02
Bilirubin (mg/dL)	3.51 (0.45–27.23)	0.230	8.02 (0.46–139.24)	0.15
Albumin (mg/dL)	0.43 (0.17–1.11)	0.080	0.48 (0.13–1.78)	0.27
Creatinine (mg/dL)	0.95 (0.84–1.08)	0.407	0.98 (0.80–1.20)	0.85
Platelet (109/L)	1.00 (0.99–1.00)	0.097	1.00 (0.99–1.00)	0.18
HDL-C: <40 mg/dL(male) or <50 mg/dL(female)	2.03 (0.98–4.20)	0.058	1.83 (0.69–4.85)	0.22
LDL (mg/dL)	0.99 (0.98–1.00)	0.034	0.99 (0.96–1.01)	0.21
Triglyceride >150 (mg/dL)	1.51 (0.80–2.87)	0.207	1.20 (0.42–3.43)	0.74
Total cholesterol (mg/dL)	0.99 (0.98–1.00)	0.093	1.00 (0.98–1.03)	0.64
Steatosis
Steatosis grade 1 (232.5 ≥CAP <255) (dB/m)	1.00 (reference)		1.00 (reference)
Steatosis grade 2 (255 ≥ CAP <290) (dB/m)	2.26 (0.96–5.32)	0.062	2.20 (0.80–6.03)	0.13
Steatosis grade 3 (≥290) (dB/m)	3.64 (1.55–8.55)	0.003	2.94 (1.00–8.63)	0.05

BMI, body mass index; DM, diabetes mellitus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HDL, High-density lipoprotein; LDL, Low-density lipoprotein; CAP, Controlled Attenuation Parameter; HBV, hepatitis B virus; HCV, hepatitis C virus.