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. 2015 Apr 8;5:9465. doi: 10.1038/srep09465

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(A) Compared with Caki-1 RCC cells that harboured wildtype VHL, TGX221 selectively inhibited the colony formation in A498 cells; (B) Compared with 786O RCC cells that harboured wildtype SETD2, TGX221 selectively inhibited the colony formation in A704 cells; (C) Xenograft tumour model using RCC cells with different VHL and SETD2 status showing selective inhibition in tumour growth by TGX221, (D) which significantly inhibited A498 tumour growth and conferred insignificant inhibition in ACHN, 786O, or Caki-1 tumours; (E) Schematic diagram of how TGX221 could linked multiple pathways/gene sets in ccRCC (*P <0.05; **P <0.01).