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. 2013 Nov 20;10(2):209–225. doi: 10.4161/auto.26929

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name kaup-10-209-g008.jpg — Figure 8. Diagram illustrating a possible role of TtVPS34 in Tetrahymena PND. Once a commitment is made to both development and PND, the zygotic micronucleus and parental macronucleus start to divide and condense, respectively. TtVPS34 plays a critical role in autophagosome formation on the parental macronucleus together with two TtATG8s, which allows digestive vesicles to incorporate with the macronuclear envelope. Both TtVPS34 and TtATG8s do not appear responsible for nuclear condensation and progeny nuclear differentiation.