Table 2. Histologic characteristics of colorectal cancers from patients in the discovery set.

	CIMP-N (N=1287, 93.9%)	CIMP-P1 (N=62, 4.6%)	CIMP-P2 (N=21, 1.5%)	P Overall	CIMP-N vs CIMP-P1	CIMP-N vs CIMP-P2	CIMP-P1 vs CIMP-P2
Differentiation				<0.001	0.022	0.217	0.996
Well differentiated	83 (6.5%)	2 (3.2%)	0 (0.0%)
Moderately differentiated	1165 (90.5%)	47 (75.8%)	17 (80.9%)
Poorly differentiated	39 (3.0%)	13 (21.0%)	4 (19.1%)
Lymphatic invasion				<0.001	<0.001	0.260	0.680
Absent	806 (62.6%)	19 (30.7%)	9 (42.9%)
Present	481 (37.4%)	43 (69.3%)	12 (57.1%)
Venous invasion				0.036	0.520	0.570	0.320
Absent	1122 (87.2%)	49 (79.0%)	21 (100.0%)
Present	165 (12.8%)	13 (21.0%)	0 (0.0%)
Perineural invasion				0.050	0.340	0.520	0.220
Absent	987 (76.7%)	41 (66.1%)	19 (90.5%)
Present	300 (23.3%)	21 (33.9%)	2 (9.5%)
Luminal necrosis				<0.001	0.330	0.130	0.600
Absent	111 (8.6%)	12 (19.4%)	7 (33.3%)
Present	1176 (91.4%)	50 (80.6%)	14 (66.7%)
Tumour budding				0.038	0.120	0.900	0.800
Absent	377 (29.3%)	9 (14.5%)	5 (23.8%)
Present	910 (70.7%)	53 (85.5%)	16 (76.2%)
Tumour-infiltrating lymphocytes				<0.001	0.013	0.001	0.252
Low (<8/HPF)	1001 (77.8%)	35 (56.4%)	7 (33.3%)
High (⩾8/HPF)	286 (22.2%)	27 (43.6%)	14 (66.7%)
Crohn-like lymphoid reaction				0.118	0.790	0.510	0.800
Absent	1101 (85.5%)	50 (80.6%)	15 (71.4%)
Present	186 (14.5%)	12 (19.4%)	6 (28.6%)
Serration				<0.001	0.024	0.226	0.996
Absent	1250 (97.1%)	48 (77.4%)	16 (76.2%)
Present	37 (2.9%)	14 (22.6%)	5 (23.8%)
Mucin production				<0.001	0.013	<0.001	0.048
Absent	1144 (88.9%)	42 (66.7%)	7 (33.3%)
Present	143 (11.1%)	21 (33.3%)	14 (66.7%)

Abbreviation: HPF=high-power field.