Table 2. Association between MMP16 expression and clinic pathological factors in the validation cohort.

Variable	n	MMP16 Expression		χ2 Value	P value
		Low	High
Gender				0.021	0.885
Male	99	50	49
Female	93	46	47
Age				0.209	0.647
≦60	65	31	34
>60	127	65	62
T category				0.457	0.499
T1/2	46	21	25
T3/4	146	75	71
N stage				9.546	0.008
N0	110	64	46
N1	55	18	37
N2	27	14	13
Pathological grading				2.225	0.329
High	88	39	49
Moderate	77	43	34
Poor	27	14	13
Lymphovascular invasion				9.733	0.002
Negative	168	91	77
Positive	24	5	19
Perineural invasion				0.669	0.413
Negative	164	84	80
Positive	28	12	16
Ki67				0.637	0.425
Negative	55	30	25
Positive	137	66	71