Figure 1. A schematic structure of the E. histolytica Gal-lectin. The Gal-lectin adhesin is composed of 3 subunits: the heavy subunit (Hgl) is linked by disulfide bonds to the light subunit (Lgl) and is non-covalently associated with the intermediate subunit (Igl). The heavy subunit has a short cytoplasmic tail and both the light and intermediate subunits are GPI anchored. TM, transmembrane; CD, cytoplasmic domain; CRD, carbohydrate rich domain; GPI, glycosylphosphatidylinisotol.