Table 1.
Focal aberrations identified by SNP, paired‐end and exome sequencing
| Patient ID | B‐cell differentiation | Cell cycle | Kinase | RAS | Cell adhesion | TP53 | Other interesting genes |
|---|---|---|---|---|---|---|---|
| P2RY8‐CRLF2 | |||||||
| 9534 | BTG1, CDKN2AB | P2RY8‐CRLF2, JAK2, IL7R | NRAS | LAMA1 | CDKN2AB | NFATC4, NCOA3 | |
| 11538 | ETV6, IKZF1, PAX5 | CDKN2AB, FOXN3 | P2RY8‐CRLF2, MAST4, STK38L, RPS6KA5 | NRAS | ITGBL1, USH2A | CDKN2AB | CRIPAK, KDM4A, SKIL, CCDC88C, SMEK1, FBLN5, CYP4A11 |
| 11706 | ETV6 | P2RY8‐CRLF2, CKMT1A, SPHKAP, NBEA, PTPRT | PTPRT | CREBBP, GLI1 | |||
| 20638 | CDKN2AB | P2RY8‐CRLF2, ACVRL1, IL7R | ITGA7, ANK2 | CDKN2AB | MLLT3, TUSC1, TOPORS, DDX58, APTX | ||
| 20753 | IKZF1, PAX5 | CDKN2A | P2RY8‐CRLF2, MAPK10 | USH2A | CDKN2A | PPP2R3B, ZEDB1, IL9R | |
| 21819 | IKZF1, PAX5, VPREB1 | CDKN2AB, MCC | P2RY8‐CRLF2, INSRR | NF1 | CDKN2AB | DDX6, CASZ1 | |
| 21991 | ETV6, VPREB1 | CDKN2AB, CCND3 | P2RY8‐CRLF2 | CD38, NPNT | CDKN2AB | ARID5A, SEMA4C, BTLA, TBL1XR1, FHIT, PAXIP1 | |
| IGH‐CRLF2 | |||||||
| 11543 | EBF1, IKZF1 | BTG1 | IGH‐CRLF2, JAK2, TTBK1 | NOX4, CHORDC1 | |||
| 19599 | IKZF1, VPREB1 | CDK13 | IGH‐CRLF2, JAK2, CDK13 | DST | TOP3A, CREB5, TRL4, CHN2, MPLKIP, INHBA, GLI3, TSC22D1 | ||
| 21245 | EBF1, ETV6, IKZF1, PAX5, VPREB1 | RB1, CDK6 | IGH‐CRLF2, JAK2, ERBB4 | CTNNA2 | RB1 | ABRA, BTLA, AFF1, MEF2C, ADD3, RUNX1 | |
| 21470 | ETV6, IKZF1, VPREB1 | IGH‐CRLF2, CRLF2, PTPN11, RHBDL2 | PTPN11 | ITGB7, LAMC2, COL3A1, CTTNBP2 | MIR181B1, MIR181A1, CADM1 | ||