Table 1.

Initial optimization of BPh₃‐catalysed reductive amination.

Entry	Solvent	Silane	Equiv. Silane	Temp. [°C]	Yield [%][a]
1	o‐DCB	PhMe2SiH	1.2	100	<5
2	MeCN	PhMe2SiH	1.2	100	33
3	o‐DCB	PhMe2SiH	3.5	100	<5
4	MeCN	PhMe2SiH	3.5	100	87 (80)[b]
5c	MeCN	PhMe2SiH	3.5	100	35
6	MeCN	PhMe2SiH	3.5	60	6
7	MeCN	Ph2SiH2	3.5	100	86
8	MeCN	Ph2MeSiH	3.5	100	8
9	MeCN	PhMeSiH2	3.5	100	55
10	MeCN	PhSiH3	3.5	100	56

Reactions performed in sealed tubes. [a] Yield by ¹H NMR spectroscopy versus mesitylene as internal standard. [b] Isolated yield. [c] Reaction at 5 mol % catalyst loading.