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. 2017 Feb 6;65(4):1165–1180. doi: 10.1002/hep.28953

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© 2016 by The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Changes to eicosanoid lipid mediators with NAFLD. Decreased n‐3 fatty acid (EPA, DHA)‐derived anti‐inflammatory eicosanoids and increased n‐6 fatty acid (AA)‐derived proinflammatory eicosanoids observed in livers from ob/ob mice and mice on an HFD. (A) Two‐way analysis of variance was performed to assess the contribution of the diet, genotype (KO) and their interaction (∼) to the metabolite changes observed. (B) Similarly, a decrease in n‐3 derived 13‐HDoHE was noted for mice following a WD, whereas no significant difference was determined for the n‐6–derived HETEs. Significantly increased n‐6 LA‐derived proinflammatory HODEs were observed in livers with NASH, compared with livers with NAFL, in human liver tissue. (C) Increased HETEs and HODEs (P < 0.1) were observed in human samples with a higher inflammation score. Data are expressed as the median ± upper/lower quartile. *P < 0.05. **P < 0.01. ***P < 0.001.