Table 1.
Examination of mPFC Gene Expression Predictors of Depression and Anxiety Behaviors in Neglected and Control Mice.
| Behavioral Endpoint | Probe | Gene | SS | Df | F | Beta | P |
|---|---|---|---|---|---|---|---|
| EPM: Number of open arm entries | ILMN_2696110 | TPPP | 0.3369 | 1 | 7.1592 | −0.0105 | 0.0112 |
| EPM: Total time on closed arms | ILMN_2696110 | TPPP | 0.2356 | 1 | 5.6595 | 0.0017 | 0.0228 |
| EPM: Total time on open arms | ILMN_2696110 | TPPP | 0.3639 | 1 | 8.3025 | −0.0021 | 0.0066 |
| FST: Total time immobile 0–5 min | ILMN_1216667 | GRIN1 | 0.0384 | 1 | 4.6504 | −0.0018 | 0.0378 |
| FST: Total time mobile 0–5 min | ILMN_2687169 | ID3 | 0.0436 | 1 | 4.6629 | −0.0009 | 0.0376 |
| FST: Total time immobile 10–15 min | ILMN_1216667 | GRIN1 | 0.0729 | 1 | 10.4221 | 0.0084 | 0.0027 |
| FST: Mean time per immobile episode | ILMN_1253164 | GRIN1 | 0.0300 | 1 | 5.2240 | −0.0043 | 0.0283 |
| FST: Number of episodes of paddling | ILMN_2696110 | TPPP | 0.4180 | 1 | 9.9525 | v0.0158 | 0.0137 |
| FST: Number of mobile episodes | ILMN_2696110 | TPPP | 0.3286 | 1 | 6.7183 | −0.0158 | 0.0137 |
Legend. TPPP gene expression predicted anxiety-like behavior on the EPM task, and GRIN1, ID3, and TPPP predicted depression-like behavior on the FST. Note: EPM = Elevated Plus Maze; FST = Forced Swim Test.