Table 1.
Clinical Subtypes (By Patient) |
Tumor Source(s) |
Race/Ethnicity (By Patient) |
|||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Academic Institution | Number Of Patients Represented |
Number of Independent PDX Available |
Estrogen Receptor Positive (Including HER2+) |
HER2 Positive Only |
"Triple Negative" |
No Data | Primary | Pleural Effusion |
Ascites | Other Metastatic Site |
Not Specified |
Caucasian | Hispanic | African American |
Continental African |
Asian | Not Reported |
Baylor College of Medicine (USA) | 42 | 51 | 10a | 5 | 26b | 1 | 37 | 2 | 2 | 1 | 0 | 10 | 21 | 9 | 0 | 0 | 2 |
Bellvitge Institute for Biomedical Research (SPAIN) |
11 | 11 | 3c | 0 | 8d | 0 | 8 | 3 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | 0 | 0 |
British Columbia Cancer Agency (CANADA) |
40 | 40 | 13 | 6 | 19 | 1 | 24 | 4 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 40 |
Ecole Polytechnique Federale De Lausanne (CH) |
2 | 2 | 1 | 0 | 1e | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
Institut Bergonié (FR) | 4 | 4 | 3 | 1 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
Institut Curie (FR) | 121 | 121 | 54 | 9 | 58f | 0 | 111 | 2 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 121 |
The Jackson Laboratory (JAX) (USA) | 29 | 32 | 7 | 1 | 20 | 1 | 22 | 0 | 0 | 4 | 3 | 21 | 1 | 0 | 0 | 2 | 5 |
MD Anderson Cancer Center (USA) - Meric-Bernstam |
26 | 29 | 13 | 0 | 13 | 0 | 24 | 0 | 0 | 5 | 0 | 10 | 2 | 13 | 0 | 1 | 0 |
MD Anderson Cancer Center (USA) - Piwnica-Wormsg,h |
23 | 26 | 0 | 0 | 23i | 0 | 24 | 0 | 0 | 1 | 0 | 12 | 3 | 6 | 0 | 2 | 0 |
Medical Campus (USA) | 25 | 25 | 11 | 1 | 12 | 1 | 20 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 25 |
University of Manchester Institute of Cancer Sciences (UK) |
20 | 20 | 11 | 1 | 8 | 0 | 12 | 1 | 7 | 0 | 0 | 18 | 0 | 0 | 0 | 0 | 2 |
University of Michigan (USA) | 20 | 21 | 3 | 3 | 14 | 0 | 15 | 5 | 0 | 1 | 0 | 6 | 0 | 4 | 9 | 0 | 1 |
University of Utah - Huntsman Cancer Institute (USA) |
16 | 20 | 6 | 2 | 8c | 0 | 7 | 9 | 1 | 3 | 0 | 14 | 2 | 0 | 0 | 0 | 0 |
Walter and Eliza Hall Institute of Medical Research (WEHI) (AU) |
59 | 62 | 19i | 6 | 34j | 0 | 58 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 59 |
Washington University (USA) | 68 | 73 | 27 | 4 | 37 | 0 | 33 | 0 | 0 | 40 | 0 | 50 | 0 | 18 | 0 | 0 | 0 |
TOTAL | 506 | 537 | 181 | 39 | 281 | 5 | 401 | 28 | 13 | 75 | 3 | 154 | 29 | 50 | 9 | 5 | 259 |
PERCENT OF TOTAL | 36 | 8 | 56 | 1 | 30 | 6 | 10 | 2 | 1 | 51 |
(2 BRCA1; 1 BRCA2)
(4 BRCA1)
(1 BRCA2)
(1 BRCA1, 1 metaplastic, 2 metaplastic mixed ductal)
Medullary
5 BRCA1, 4 BRCA2, 4 metaplastic
Defined as "Stable" at passage 2
All treatment naïve
(4 BRCA1; 1 BRCA2)
(1 BRCA2)
(8 BRCA1; 1 BRCA2; 2 metaplastic)