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Effect of p53 knockdown or knockout on APAP metabolism. A. Immunoblotting of cyp2e1 after PFTα treatment. B. Immunoblotting of cyp2e1 in both WT and p53 KO mice. C. The levels of GSH in the liver of both WT and p53 KO mice. Comparison of WT and p53 KO group showed no significant differences. D. Immunoblot of NAPQI adducts. Times shown are after APAP dosing.
