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Effect of nutlin-3a induced p53 on APAP toxicity (C57BL/6J). A. Increased p53 6h after nutlin-3a treatment in vivo; the right panel shows densitometry of /β-actin of n=3, *p<0.05. B, C The ALT level and H&E histology at 24h. (n=10 mice, **P<0.01) D. The levels of GSH in the liver after nutlin-3a treatment. (n=3 mice) E. The activation of JNK at 6h after APAP injection in mice after nutlin-3a 1h pretreatment. Bar graphs at right shows densitometry of p-JNK/JNK of n =3, *p<0.05.
