. 2016 Nov 30;13(1):167–176. doi: 10.3892/ol.2016.5447

Table IV.

Interacting pairs of pathways with top 10 weights.

Pathway 1 and description	Pathway 2 and description	Weight	Co-genes
hsa05323:	hsa04620:	0.492651941	CTSK^a/CTSO^a/FOS/IL8^a/TLR2^a
Rheumatoid arthritis	Toll-like receptor signaling pathway
hsa05142:	hsa04620:	0.464920784	IL8^a/TLR2^a/FOS
Chagas disease (American trypanosomiasis)	Toll-like receptor signaling pathway
hsa05146:	hsa04620:	0.37284676	IL8^a/TLR2^a/CD14^a
Amoebiasis	Toll-like receptor signaling pathway
hsa04620	hsa04060:	0.351558647	IL8^a/CXCL10^a
Toll-like receptor signaling pathway	Cytokine-cytokine receptor interaction
hsa04062:	hsa04060:	0.33933744	CCR1^a/CXCL1^a/CXCL3^a/IL8^a/
Chemokine signaling pathway	Cytokine-cytokine receptor interaction		CXCL10^a/CCL28/CCL8^a/CCL13^a/CCL18^a/CCL21/CXCL5^a
hsa04380:	hsa04620:	0.327230722	CTSK^a/FOS
Osteoclast differentiation	Toll-like receptor signaling pathway
hsa04974:	hsa04512:	0.31737287	COL5A1^a/COL6A3^a/COL11A1^a/
Protein digestion and absorption	ECM-receptor interaction		COL5A3^a
hsa04512:	hsa04510:	0.307854633	COL5A1^a/COL6A3^a/COL11A1^a/
ECM-receptor interaction	Focal adhesion		COMP^a/TNC^a/IBSP^a/ITGA2^a/ITGA4^a/ITGA5^a/LAMB3^a/COL5A3^a/RELN/SPP1^a/THBS2^a/
hsa04145:	hsa04620:	0.305699295	TLR2^a/CD14^a
Phagosome	Toll-like receptor signaling pathway
hsa05150:	hsa04610:	0.272281647	CFD/C1QA^a/C1QB^a/C1QC^a/
Staphylococcus aureus infection	Complement and coagulation cascades		C3AR1^a/C5AR1^a

Downregulated differentially expressed genes. ECM, extracellular matrix.