Table 2. mAb neutralization of B/Victoria escape mutants.
| Virus1 | mAb2 | |||
|---|---|---|---|---|
| BR5A1 | BR8E12 | BR7B7 | CR2F11 | |
| B/Brisbane | + | + | + | + |
| 5A1v (K203R) | - | - | - | - |
| 8E12v (P241Q) | + | - | - | - |
| 7B7v (N233S) | + | + | - | + |
| 2F11v (D197Y) | + | + | + | - |
1 Each virus was titrated and diluted to approximately 500 pfu/ml and incubated with mAb concentrations from 80 to 0.31 μg/ml for incubation with mAb.
2 Each mAb completely neutralized B/Brisbane at concentrations between 1.25–5 μg/ml (scored + in the Table); escape mutants requiring a 10-fold or greater concentration of mAb for neutralization (relative to B/Brisbane neutralization) were scored negative (resistant to mAb neutralization).