Table 2. Determinants of measures of renal outcome including the presence/absence of Metabolic Syndrome and/or Hyperuricemia.
| eGFR <60 mL/min/1.73m2 | Albuminuria | |||
|---|---|---|---|---|
| OR (95%CI) | p | OR (95%CI) | p | |
| 1HU-Mets- | Reference | - | Reference | - |
| 2HU-Mets+ | 1.16 (0.99–1.36) | 0.069 | 1.02 (0.91–1.14) | 0.766 |
| 3HU+Mets- | 1.57 (1.23–1.99) | <0.001 | 1.00 (0.81–1.22) | 0.964 |
| 4HU+Mets+ | 1.30 (1.07–1.59) | 0.009 | 1.25 (1.07–1.46) | 0.005 |
| Systolic BP (by 10 mmHg) | 1.07 (1.03–1.11) | <0.001 | 1.06 (1.03–1.09) | <0.001 |
| Diastolic BP (by 10 mmHg) | 0.92 (0.85–0.99) | 0.034 | 0.96 (0.90–1.02) | 0.164 |
| HDL (by 5 mg/dL) | 0.97 (0.95–0.99) | 0.006 | 0.96 (0.95–0.98) | <0.001 |
| Triglycerides (by 50 mg/dL) | 1.06 (1.03–1.09) | <0.001 | 1.03 (1.01–1.05) | 0.013 |
| BMI (by 5 Kg/m2) | 1.11 (1.04–1.19) | 0.002 | 1.10 (1.05–1.16) | <0.001 |
| Male sex | 0.76 (0.67–0.85) | <0.001 | 1.37 (1.25–1.49) | <0.001 |
| Age (by 10 years) | 1.53 (1.41–1.65) | <0.001 | 1.19 (1.13–1.26) | <0.001 |
| Known duration of diabetes (by 10 years) | 1.11 (1.03–1.18) | 0.003 | 1.02 (0.97–1.08) | 0.398 |
| eGFR (by 10 mL/min/1.73 m2) | 0.40 (0.38–0.42) | <0.001 | 1.01 (0.97–1.04) | 0.791 |
| HbA1c (by 1%) | 1.12 (1.07–1.18) | <0.001 | 1.12 (1.08–1.16) | <0.001 |
Multivariate models. BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein cholesterol; HU, serum uric acid in the top gender-specific quintile; LDL, low-density lipoprotein cholesterol; Mets, Metabolic syndrome. Complete-case analysis performed excluding 273 patients with incomplete data.