Table 2. Univariate and multivariate analysis of predictors of EGFR mutation.

Characteristic		WT	EGFR m+	Univariate analysis		Multivariate analysis
		(n = 317)		Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value
Age (years)
	≤ 65	143	137	1
	> 65	174	197	1.182 (0.866–1.613)	0.292
Sex
	Female	136	210	1
	Male	181	124	0.444 (0.323–0.607)	< 0.001
Smoking
	≤ 5 PY	131	229	1		1
	> 5 PY	186	105	0.323 (0.234–0.444)	< 0.001	0.357 (0.256–0.494)	< 0.001
Serum CEA level
	Normal	157	197	1
	Elevated	160	137	0.682 (0.500–0.930)	0.016
Tumor size
	< 30 mm	218	243	1
	≥ 30 mm	99	91	0.825 (0.587–1.156)	0.264
Pathological nodal status
	N0	232	277	1
	N1 / N2	85	57	0.562 (0.383–0.818)	0.003
Lymphatic permeation
	Negative	221	253	1
	Positive	96	81	0.737 (0.521–1.041)	0.084
Vascular invasion
	Negative	204	251	1
	Positive	113	83	0.597 (0.425–0.836)	0.003
SUVmax
	≤ 2.69	124	200	1		1
	> 2.69	193	134

WT = wild-type; m⁺ = mutation-positive; PY = pack years.