Table 7.

Laboratory test parameters, blood pressure, and pulse rate data with significant differences in the intergroup comparisons

	Placebo	SFPP
		10 mg	20 mg	40 mg
Eosinophil, %
n	127	121	127	134
Baseline (3rd visit)	2.7 ± 2.1	2.8 ± 2.1	3.1 ± 2.0	3.0 ± 2.1
End of the study	2.6 ± 1.8	3.0 ± 1.9	3.4 ± 2.1	3.1 ± 2.0
Comparisons with placebo: P-value*	–	0.014	0.008	0.121
Platelet, 104/μL
n	127	121	127	134
Baseline (3rd visit)	23.50 ± 5.03	23.83 ± 5.95	23.54 ± 4.66	23.32 ± 4.74
End of the study	23.53 ± 4.95	23.57 ± 6.03	22.98 ± 4.52	22.90 ± 4.74
Comparisons with placebo: P-value*	–	0.369	0.044	0.119
LDH, IU/L
n	127	120	127	134
Baseline (3rd visit)	200.9 ± 34.4	198.8 ± 30.2	197.2 ± 29.5	200.6 ± 32.0
End of the study	200.6 ± 41.1	201.2 ± 29.7	200.3 ± 30.8	205.9 ± 32.7
Comparisons with placebo: P-value*	–	0.328	0.208	0.045
BUN, mg/dL
n	127	120	127	134
Baseline (3rd visit)	17.2 ± 4.5	15.4 ± 3.7	16.5 ± 4.0	16.3 ± 3.7
End of the study	17.1 ± 4.4	17.2 ± 3.9	17.7 ± 4.1	18.0 ± 4.2
Comparisons with placebo: P-value*	–	<0.001	0.009	<0.001
Total protein, g/dL
n	127	120	127	134
Baseline (3rd visit)	7.13 ± 0.44	7.14 ± 0.48	7.14 ± 0.40	7.17 ± 0.41
End of the study	7.14 ± 0.41	7.13 ± 0.50	7.07 ± 0.41	7.09 ± 0.38
Comparisons with placebo: P-value*	–	0.664	0.047	0.025
Cl, mEq/L
n	127	120	127	134
Baseline (3rd visit)	104.5 ± 2.4	104.5 ± 2.5	104.6 ± 2.2	104.3 ± 2.6
End of the study	104.4 ± 2.4	104.6 ± 2.5	104.7 ± 2.0	104.8 ± 2.3
Comparisons with placebo: P-value*	–	0.811	0.616	0.018
Systolic blood pressure, mm Hg
n	127	121	127	133
Baseline (3rd visit)	132.7 ± 16.0	132.5 ± 16.3	129.2 ± 16.2	133.1 ± 17.8
End of the study	130.7 ± 16.7	132.0 ± 16.2	131.3 ± 16.6	133.7 ± 17.0
Comparisons with placebo: P-value*	–	0.377	0.009	0.126

Notes: Values “at baseline” and “at the end of the study” are the mean ± standard deviation.

^*Student’s t-test (significance levels = 0.05 [two-sided]).

Abbreviations: SFPP, S-flurbiprofen plaster; LDH, Lactate dehydrogenase; BUN, Blood urea nitrogen; Cl, Chloride; SFPP, S-flurbiprofen plaster.