Table 1.
Allele and genotype frequencies and comparison between Russian acute coronary syndrome patients according to geographical region: Moscow region, Northern, Central, and Eastern Siberia (Fisher’s exact test)
| Allele and genotype n (%) | Geographical region of residence | |||
|---|---|---|---|---|
| CYP2C19*2 | Northern Siberia | Central Siberia | Eastern Siberia | Moscow region |
| N | 87 | 222 | 122 | 81 |
| *1/*1 | 63 (72.4) | 173 (77.9) | 97 (79.5) | 68 (84.0) |
| *1/*2 | 22 (25.3) | 49 (22.1) | 24 (19.7) | 13 (16.0) |
| *2*/2 | 2 (2.3) | 0 (0.0) | 1 (0.8) | 0 (0.0) |
| *2 (%) | 14.9 | 11.5 | 10.6 | 8.0 |
| Central Siberia | p=0.307; OR=0.92 (95% CI 0.8–1.07)a | NA | NA | NA |
| Eastern Siberia | p=0.24; OR=0.91 (95% CI 0.77–1.06) | p=0.78; OR=0.98 (95% CI 0.87–1.09) | NA | NA |
| Moscow region | p=0.09; OR=0.86 (95% CI 0.73–1.01) | p=0.33; OR=0.92 (95% CI 0.82–1.04) | p=0.46; OR=0.94 (95% CI 0.83–1.08) | NA |
| CYP2C19*3 | – | – | – | – |
| *1/*1 | 86 (98.9) | 222 (100.0) | 116 (95.1) | 81 (100.0) |
| *1/*3 | 1 (1.1) | 0 (0.0) | 5 (4.1) | 0 (0.0) |
| *3*/3 | 0 (0.0) | 0 (0.0) | 1 (0.8) | 0 (0.0) |
| *3 (%) | 0.5 | 0.0 | 2.8 | 0.0 |
| Central Siberia | p=0.28; OR=0.98 (95% CI 0.96–1.01) | NA | NA | NA |
| Eastern Siberia | p=0.24; OR=1.01 (95% CI 0.99–1.08) | p=0.001; OR=1.05 (95% CI 1.01–1.09) | NA | NA |
| Moscow region | p=1.0; OR=0.98 (95% CI 0.96–1.01) | Comparison impossible | p=0.46; OR=0.94 (95% CI 0.83–1.08) | NA |
| CYP2C19*17 | – | – | – | – |
| *1/*1 | 44 (50.6) | 153 (68.9) | 73 (59.8) | 57 (70.4) |
| *1/*17 | 28 (32.2) | 62 (27.9) | 43 (35.2) | 23 (28.4) |
| *17*/*17 | 15 (17.2) | 7 (3.2) | 6 (4.9) | 1 (1.2) |
| *17 (%) | 33.3 | 17.1 | 22.2 | 15.4 |
| Central Siberia | p=0.07; OR=0.82 (95% CI 0.67–1.02) | NA | NA | NA |
| Eastern Siberia | p=0.76; OR=0.95 (95% CI 0.74–1.21) | p=0.09; OR=1.15 (95% CI 0.97–1.36) | NA | NA |
| Moscow region | p=0.09; OR=0.81 (95% CI 0.63–1.03) | p=0.88; OR=0.97 (95% CI 0.82–1.15) | p=0.13; OR=0.85 (95% CI 0.69–1.04) | NA |
Note:
a
Fisher’s exact test not applicable.
Abbreviations: CI, confidence interval; NA, not applicable; OR, odds ratio.